The SENP7 Polyclonal Antibody (PACO01482) is a valuable tool for researchers studying SENP7, a key player in the SUMOylation pathway. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications.SENP7 is a SUMO-specific protease that plays a crucial role in the regulation of protein SUMOylation, a post-translational modification involved in various cellular processes such as gene expression, DNA repair, and stress responses. Dysregulation of SUMOylation has been implicated in various diseases including cancer, neurodegenerative disorders, and viral infections, making SENP7 an important target for investigation.
By targeting SENP7, researchers can gain insights into the mechanisms underlying SUMOylation and its impact on cellular function and disease development. This antibody enables detection and analysis of SENP7 in different cell types, providing a valuable tool for studies in molecular biology, cellular signaling, and disease mechanisms.
Antibody Name:
SENP7 Antibody
Antibody SKU:
PACO01482
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human SENP7.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
NCBI Summary:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
