SENP6 Rabbit Polyclonal Antibody (CAB17673)
- SKU:
- CAB17673
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SENP6 Rabbit Polyclonal Antibody |
SKU: | CAB17673 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2). |
Sequence: | MESC SQNS SAKP VIKK MLNK KHCI AVID SNPG QEES DPRY KRNI CSVK YSVK KINH TASE NEEF NKGE STSQ KVAD RTKS ENGL QNES LSST HHTD GLSK IRLN YSDE SPEA GKML EDEL VDFS EDQD NQDD SSDD GFLA DDNC SSEI GQWH LKPT ICKQ PCIL LMDS LRGP SRSN VVKI LREY LEVE WEVK KGSK RSFS KDVM KGSN PKVP QQNN FSDC GVYV LQYV ESFF ENPI LSFE LPMN LANW FPPP RMRT KREE IRNI ILKL QEDQ SKEK RKHK DTYS TEAP LGEG TEQY VNSI SD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SSP1; SUSP1; SENP6 |
Positive Sample: | Rat thymus,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus |
Calculated MW: | 126kDa |
Observed MW: | 126kDa |
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).
Purification Method: | Affinity purification |
Gene ID: | 26054 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |