The SENP5 Antibody (PAC023148) is a valuable tool for researchers studying the SENP5 protein, a crucial component in the regulation of the SUMOylation process. This polyclonal antibody, produced in rabbits, has high specificity and sensitivity for detecting SENP5 in human samples, making it ideal for use in various research applications, including Western blot analysis.SENP5, a member of the SUMO-specific protease family, plays a key role in the removal of SUMO protein modifications, which are essential for regulating numerous cellular processes, including gene expression, DNA repair, and protein stability.
Dysregulation of SENP5 has been linked to various diseases, making it a promising target for investigations into cancer, neurodegenerative disorders, and other pathologies.By using the SENP5 Antibody, researchers can gain valuable insights into the function and regulation of SENP5, providing opportunities for the development of novel therapeutic strategies targeting the SUMOylation pathway. This antibody is a valuable asset for studies in molecular biology, cell biology, and disease mechanisms, offering a reliable tool for uncovering the role of SENP5 in health and disease.
Synthesized peptide derived from Internal of human SENP5.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COS7 cells, using SENP5 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SENP5 antibody.
Background:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Synonyms:
EC 3.4.22.-; SUMO1/sentrin specific peptidase 5;
UniProt Protein Function:
SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family.
Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity
Biological Process: protein desumoylation; protein sumoylation
NCBI Summary:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
