The SENP1 Polyclonal Antibody (CAB13086) is a valuable tool for researchers studying SENP1, a key enzyme involved in the regulation of protein SUMOylation, a process critical for various cellular functions. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the SENP1 protein, researchers can detect and analyze its expression in different cellular contexts, providing insights into its role in cellular processes such as DNA repair, cell cycle regulation, and stress responses.SENP1, a member of the SENP family of proteases, has been shown to play a crucial role in maintaining cellular homeostasis by controlling the dynamics of SUMOylation, a post-translational modification that regulates protein localization, stability, and function.
Dysregulation of SENP1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, making it a promising therapeutic target for drug development and precision medicine strategies.Overall, the SENP1 Polyclonal Antibody (CAB13086) offers a reliable and specific tool for researchers investigating the complex role of SENP1 in cellular physiology and pathology, opening up new avenues for understanding disease mechanisms and developing targeted therapies.
Product Name:
SENP1 Rabbit Polyclonal Antibody
SKU:
CAB13086
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1 (NP_001254523.1).
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
29843
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SENP1 Rabbit pAb (CAB13086) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
