SEMA4A Rabbit Polyclonal Antibody (CAB17205)
- SKU:
- CAB17205
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SEMA4A Rabbit Polyclonal Antibody |
SKU: | CAB17205 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2). |
Sequence: | IYAV FTSQ WQVG GTRS SAVC AFSL LDIE RVFK GKYK ELNK ETSR WTTY RGPE TNPR PGSC SVGP SSDK ALTF MKDH FLMD EQVV GTPL LVKS GVEY TRLA VETA QGLD GHSH LVMY LGTT TGSL HKAV VSGD SSAH LVEE IQLF PDPE PVRN LQLA PTQG AVFV GFSG GVWR VPRA NCSV YESC VDCV LARD PHCA WDPE SRTC CLLS APNL NSWK QDME RGNP EWAC ASGP MSRS LRPQ SRPQ IIKE VLAV PNSI LELP C |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | RP35; SEMB; SEMAB; CORD10; SEMA4A |
Positive Sample: | HT-29 |
Cellular Localization: | extracellular space, plasma membrane |
Calculated MW: | 84kDa |
Observed MW: | 83kDa |
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 64218 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |