SEMA3C Rabbit Polyclonal Antibody (CAB15386)
- SKU:
- CAB15386
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | SEMA3C Rabbit Polyclonal Antibody |
SKU: | CAB15386 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-330 of human SEMA3C (NP_006370.1). |
Sequence: | GSSQ PQAR VYLT FDEL RETK TSEY FSLS HHPL DYRI LLMD EDQD RIYV GSKD HILS LNIN NISQ EALS VFWP ASTI KVEE CKMA GKDP THGC GNFV RVIQ TFNR THLY VCGS GAFS PVCT YLNR GRRS EDQV FMID SKCE SGKG RCSF NPNV NTVS VMIN EELF SGMY IDFM GTDA AIFR SLTK RNAV RTDQ HNSK WLSE PMFV DAHV IPDG TDPN DAKV YFFF KEKL TDNN RSTK QIHS MIAR ICPN DTGG LRSL VNKW TTFL KARL VCSV TDED GPET HFDE LEDV FLLE TDNP RTTL VYGI FTTS SS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | SemE; SEMAE; SEMA3C |
Positive Sample: | Human serum |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 85kDa |
Observed MW: | 85kDa |
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.
Purification Method: | Affinity purification |
Gene ID: | 10512 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |