The SEMA3C Polyclonal Antibody (CAB15386) is a valuable tool for researchers studying SEMA3C, a member of the semaphorin protein family that plays a crucial role in cell signaling and axon guidance. This antibody, produced in rabbits, is highly specific for SEMA3C and has been validated for use in Western blot and immunohistochemistry applications. It binds to the SEMA3C protein, allowing for accurate detection and analysis in a variety of cell types.SEMA3C is known for its involvement in processes such as cell migration, angiogenesis, and neuronal development, making it a key player in various physiological and pathological conditions.
Its dysregulation has been linked to cancer progression, neurological disorders, and cardiovascular diseases, highlighting its potential as a therapeutic target. By studying the function of SEMA3C using this antibody, researchers can gain insights into its role in disease pathology and explore novel treatment strategies.Overall, the SEMA3C Polyclonal Antibody is an essential tool for investigating the functions and mechanisms of SEMA3C in various biological processes, making it a valuable resource for studies in cell biology, cancer research, and developmental biology.
Product Name:
SEMA3C Rabbit Polyclonal Antibody
SKU:
CAB15386
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-330 of human SEMA3C (NP_006370.1).
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.
Purification Method:
Affinity purification
Gene ID:
10512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Human serum, using SEMA3C Rabbit pAb (CAB15386) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
