The SELP Polyclonal Antibody (CAB1425) is a valuable tool for researchers studying the SELP protein, also known as P-selectin. P-selectin is a cell adhesion molecule involved in inflammatory responses and the recruitment of immune cells to sites of injury or infection. This antibody, produced in rabbits, is highly specific to human SELP and has been validated for use in Western blot applications.By binding to the SELP protein, this antibody enables the detection and analysis of SELP expression in various cell types, making it ideal for studies related to inflammation, immune response, and vascular biology.
Understanding the role of P-selectin in these processes is essential for developing new treatments for inflammatory disorders, cardiovascular diseases, and conditions involving abnormal immune cell recruitment.Researchers can rely on the SELP Polyclonal Antibody (CAB1425) to help unravel the complexities of SELP function and explore its potential as a therapeutic target in various disease models. With its high specificity and sensitivity, this antibody provides a valuable tool for advancing our understanding of P-selectin biology and its implications for human health.
Product Name:
CD62P/P-selectin Rabbit Polyclonal Antibody
SKU:
CAB1425
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human CD62P/P-selectin (NP_002996.2).
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Purification Method:
Affinity purification
Gene ID:
6403
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD62P/P-selectin Rabbit pAb (CAB1425) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
