The SELP Polyclonal Antibody (CAB12512) is a valuable tool for research focused on SELP, a cell adhesion molecule important in immune response and inflammatory processes. This antibody, generated in rabbits, is highly specific for SELP in human samples and is validated for use in various applications such as Western blotting.SELP, also known as P-selectin, plays a crucial role in mediating the interaction between immune cells and endothelial cells during inflammation. Its involvement in recruiting leukocytes to sites of inflammation makes it a key player in immune response regulation.
Research on SELP is particularly relevant in understanding the mechanisms underlying various inflammatory diseases, such as atherosclerosis, asthma, and arthritis.By using the SELP Polyclonal Antibody, researchers can study the expression and function of SELP in different cell types and tissues, providing insights into its role in health and disease. This antibody is an essential tool for investigations in immunology, vascular biology, and inflammation, offering valuable information for the development of targeted therapies for inflammatory conditions.
Product Name:
CD62P/P-selectin Rabbit Polyclonal Antibody
SKU:
CAB12512
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-319 of human CD62P/P-selectin (NP_002996.2).
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Purification Method:
Affinity purification
Gene ID:
6403
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD62P/P-selectin antibody (CAB12512) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5s.
