The E-Selectin Polyclonal Antibody (CAB2191) is a valuable tool for researchers studying E-Selectin, a cell adhesion molecule involved in inflammatory responses and leukocyte recruitment. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to the E-Selectin protein, this antibody allows for the detection and analysis of E-Selectin expression in various cell types, making it ideal for investigations in immunology and vascular biology.E-Selectin plays a crucial role in the adhesion of leukocytes to the endothelium during inflammation, making it a key player in the immune response and the development of inflammatory diseases.
Research on E-Selectin can provide insights into the mechanisms of inflammatory processes and facilitate the development of therapeutic strategies for conditions such as atherosclerosis, arthritis, and inflammatory bowel disease. The E-Selectin Polyclonal Antibody is a valuable tool for scientists seeking to unravel the functions of E-Selectin in health and disease.
Product Name:
SELE Rabbit Polyclonal Antibody
SKU:
CAB2191
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-230 of human SELE (NP_000441.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
67kDa
Observed MW:
67kDa
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Purification Method:
Affinity purification
Gene ID:
6401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from SK-BR-3 cells, using SELE Rabbit pAb (CAB2191) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
