The SEL1L Polyclonal Antibody (CAB12073) is a valuable tool for researchers studying SEL1L, a crucial protein involved in protein quality control and ER-associated degradation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SEL1L protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential reagent for investigations in the fields of cell biology and protein degradation pathways.
SEL1L is a key component of the ERAD pathway, playing a vital role in the degradation of misfolded proteins and maintaining cellular homeostasis. Dysregulation of SEL1L has been implicated in various diseases, including neurodegenerative disorders and cancer. By studying the function and regulation of SEL1L using this antibody, researchers can gain insights into the mechanisms underlying protein quality control and develop targeted therapies for diseases associated with protein misfolding and accumulation.
Product Name:
SEL1L Rabbit Polyclonal Antibody
SKU:
CAB12073
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3).
Endoplasmic reticulum membrane, Single-pass type I membrane protein.
Calculated MW:
89kDa
Observed MW:
100kDa
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6400
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SEL1L Rabbit pAb (CAB12073) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
