PTTG1 Rabbit Polyclonal Antibody (CAB8307)
- SKU:
- CAB8307
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | PTTG1 Rabbit Polyclonal Antibody |
SKU: | CAB8307 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human PTTG1 (NP_001269311.1). |
Sequence: | MATL IYVD KENG EPGT RVVA KDGL KLGS GPSI KALD GRSQ VSTP RFGK TFDA PPAL PKAT RKAL GTVN RATE KSVK TKGP LKQK QPSF SAKK MTEK TVKA KSSV PASD DAYP EIEK FFPF NPLD FESF DLPE EHQI AHLP LSGV PLMI LDEE RELE KLFQ LGPP SPVK MPSP PWES NLLQ SPSS ILST LDVE LPPV CCDI DI |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 |
Synonyms: | EAP1; PTTG; ECRAR; HPTTG; TUTR1; PTTG1 |
Positive Sample: | SW480,Jurkat,HeLa,Mouse stomach,Mouse thymus,Mouse spleen,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 24kDa |
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9232 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |