SECISBP2 Rabbit Polyclonal Antibody (CAB6736)
- SKU:
- CAB6736
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | SECISBP2 Rabbit Polyclonal Antibody |
SKU: | CAB6736 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human SECISBP2 (NP_076982.3). |
Sequence: | DELI STPS VEDK SEEP PGTE LQRD TEAS HLAP NHTT FPKI HSRR FRDY CSQM LSKE VDAC VTDL LKEL VRFQ DRMY QKDP VKAK TKRR LVLG LREV LKHL KLKK LKCV IISP NCEK IQSK GGLD DTLH TIID YACE QNIP FVFA LNRK ALGR SLNK AVPV SVVG IFSY DGAQ DQFH KMVE LTVA ARQA YKTM LENV QQEL VGEP RPQA PPSL PTQG PSCP AEDG PPAL KEKE EPHY IEIW KKHL EAYS GCTL ELEE SLEA STSQ MMNL NL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | SBP2; THMA1; SECISBP2 |
Positive Sample: | HeLa,Mouse testis,Mouse thymus,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion, Nucleus. |
Calculated MW: | 95kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 79048 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |