The SECISBP2 Polyclonal Antibody (CAB6736) is a versatile tool for researchers studying SECISBP2, a crucial player in selenoprotein synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the SECISBP2 protein, this antibody allows for the detection and analysis of SECISBP2 in a variety of cell types, making it an essential component of studies in molecular biology and biochemistry.SECISBP2 is a key factor in the translation of selenoproteins, which are essential for various biological processes, including antioxidant defense and thyroid hormone regulation.
Dysregulation of selenoprotein synthesis is linked to a range of diseases, making SECISBP2 an attractive target for research in areas such as cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the role of SECISBP2 is crucial for unveiling the mechanisms underlying these conditions and developing potential therapeutic interventions.
Product Name:
SECISBP2 Rabbit Polyclonal Antibody
SKU:
CAB6736
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 585-854 of human SECISBP2 (NP_076982.3).
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SECISBP2 Rabbit pAb (CAB6736) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
