The Sec62 Polyclonal Antibody (CAB18589) is a valuable tool for researchers studying the Sec62 protein, a key component of the endoplasmic reticulum (ER) protein translocation machinery. This rabbit-derived antibody is highly specific and reactive with human samples, making it an ideal choice for use in Western blot applications.Sec62 is essential for protein translocation into the ER and plays a crucial role in maintaining cellular homeostasis. Dysregulation of Sec62 has been implicated in various diseases, including cancer and neurodegenerative disorders.
By using the Sec62 Polyclonal Antibody, researchers can better understand the function of Sec62 in cellular processes and disease pathogenesis.This antibody enables the detection and analysis of Sec62 in various cell types, providing valuable insights for studies in cell biology, protein trafficking, and disease mechanisms. Its high specificity and sensitivity make it a reliable tool for investigating the role of Sec62 in health and disease.
Product Name:
SEC62 Rabbit Polyclonal Antibody
SKU:
CAB18589
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 258-399 of human SEC62 (NP_003253.1).
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Purification Method:
Affinity purification
Gene ID:
7095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SEC62 Rabbit pAb (CAB18589) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
