The SEC61B Polyclonal Antibody (CAB15788) is a powerful tool for researchers studying the SEC61B protein, a critical component of the endoplasmic reticulum involved in protein translocation. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications.The SEC61B antibody binds specifically to the SEC61B protein, enabling precise detection and analysis in a variety of cell types. This makes it an invaluable asset for studies related to protein trafficking, protein folding, and quality control in the endoplasmic reticulum. Researchers in the fields of cell biology, molecular biology, and biochemistry will find this antibody indispensable for their work.
By utilizing the SEC61B antibody, scientists can gain deeper insights into the mechanisms underlying protein translocation and processing within cells. This knowledge is crucial for understanding various cellular processes and may have implications for diseases related to protein misfolding and trafficking, such as neurodegenerative disorders. Invest in the SEC61B Polyclonal Antibody (CAB15788) to enhance your research efforts and advance our understanding of cellular biology.
Product Name:
[KO Validated] SEC61B Rabbit Polyclonal Antibody
SKU:
CAB15788
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-96 of human SEC61B (NP_006799.1).
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Purification Method:
Affinity purification
Gene ID:
10952
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and SEC61B knockout (KO) 293T cells, using [KO Validated] SEC61B Rabbit pAb (CAB15788) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
