The SEC61A1 Polyclonal Antibody (CAB11614) is a valuable tool for researchers studying SEC61A1, a key component of the protein translocation machinery in the endoplasmic reticulum. This antibody is produced in rabbits and shows high reactivity with human samples, making it an excellent choice for Western blot applications. By specifically binding to the SEC61A1 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studies in cell biology and protein translocation mechanisms.
SEC61A1 is a crucial protein involved in the translocation of nascent proteins across the endoplasmic reticulum membrane, playing a vital role in maintaining cellular homeostasis. Dysregulation of SEC61A1 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention. By investigating the function and expression of SEC61A1, researchers can gain valuable insights into disease mechanisms and potentially develop new treatment strategies.
Product Name:
SEC61A1 Rabbit Polyclonal Antibody
SKU:
CAB11614
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 310-420 of human SEC61A1 (NP_037468.1).
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.
Purification Method:
Affinity purification
Gene ID:
29927
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using SEC61A1 Rabbit pAb (CAB11614) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
