SEC31A Rabbit Polyclonal Antibody (CAB9321)
- SKU:
- CAB9321
- Product Type:
- Antibody
- Applications:
- WB
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SEC31A Rabbit Polyclonal Antibody |
SKU: | CAB9321 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human SEC31A (NP_055748.2). |
Sequence: | PTNT QWCF DIQW CPRN PAVL SAAS FDGR ISVY SIMG GSTD GLRQ KQVD KLSS SFGN LDPF GTGQ PLPP LQIP QQTA QHSI VLPL KKPP KWIR RPVG ASFS FGGK LVTF ENVR MPSH QGAE QQQQ QHHV FISQ VVTE KEFL SRSD QLQQ AVQS QGFI NYCQ KKID ASQT EFEK NVWS FLKV NFED DSRG KYLE LLGY RKED L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1; SEC31A |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | COPII-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Peripheral membrane protein. |
Calculated MW: | 133kDa |
Observed MW: | 165kDa |
The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 22872 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |