SDHB Rabbit Polyclonal Antibody (CAB10821)
- SKU:
- CAB10821
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SDHB Rabbit Polyclonal Antibody |
SKU: | CAB10821 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2). |
Sequence: | AQTA AATA PRIK KFAI YRWD PDKA GDKP HMQT YEVD LNKC GPMV LDAL IKIK NEVD STLT FRRS CREG ICGS CAMN INGG NTLA CTRR IDTN LNKV SKIY PLPH MYVI KDLV PDLS NFYA QYKS IEPY LKKK DESQ EGKQ QYLQ SIEE REKL DGLY ECIL CACC STSC PSYW WNGD KYLG PAVL MQAY RWMI DSRD DFTE ERLA KLQD PFSL YRCH TIMN CTRT CPKG LNPG KAIA EIKK MMAT YKEK KASV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP; MC2DN4; SDHB |
Positive Sample: | HepG2,Jurkat,Mouse liver,Mouse kidney,Mouse heart,Rat kidney,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein. |
Calculated MW: | 32kDa |
Observed MW: | 32kDa |
This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency.
Purification Method: | Affinity purification |
Gene ID: | 6390 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |