The SDCCAG8 Polyclonal Antibody (PACO12071) is a powerful tool for researchers studying SDCCAG8, a protein that plays a crucial role in ciliogenesis and cilia function. This antibody is specifically designed for use in Western blot applications and has been validated for its high reactivity with human samples. By binding to the SDCCAG8 protein, this antibody allows for the detection and analysis of SDCCAG8 in a variety of cell types, making it ideal for research in cell biology and developmental biology.SDCCAG8 is an essential component of the ciliary transition zone, a structure that regulates the entry and exit of proteins in and out of the ciliary compartment. Dysregulation of SDCCAG8 has been linked to various ciliopathy disorders, including Joubert syndrome and Meckel-Gruber syndrome.
By studying the function of SDCCAG8, researchers can gain valuable insights into the mechanisms underlying these disorders and potentially uncover new therapeutic targets for treating ciliopathies.Overall, the SDCCAG8 Polyclonal Antibody (PACO12071) is a valuable tool for researchers interested in unraveling the complexities of cilia biology and its implications for human health. Its high reactivity and specificity make it a reliable choice for studying SDCCAG8 in the context of ciliogenesis, ciliary function, and ciliopathy disorders.
serologically defined colon cancer antigen 8;SDCCAG8;CCCAP;HSPC085;NY-CO-8 ;
UniProt Protein Function:
SDCCAG8: Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis. Defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7 (SLSN7). SLSN7 is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q43Cellular Component: centriole; centrosome; cytosol; intercellular junctionMolecular Function: protein bindingBiological Process: establishment of cell polarity; G2/M transition of mitotic cell cycle; lumen formationDisease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 16; Senior-loken Syndrome 7
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
