Based on the information provided in the URL, the SDCBP2 Polyclonal Antibody (PAC041054) is a valuable tool for researchers studying SDCBP2, a protein involved in various cellular processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications.SDCBP2, also known as Syntenin-2, is known to play a role in cell signaling, cell adhesion, and intracellular trafficking. It has been implicated in cancer progression, metastasis, and tumor growth, making it a promising target for cancer research. By utilizing this antibody, researchers can detect and analyze SDCBP2 expression in different cell types, providing valuable insights into its function and potential as a therapeutic target in cancer treatment.
Understanding the role of SDCBP2 in cellular processes and its involvement in cancer development is crucial for advancing our knowledge of cancer biology and identifying new therapeutic strategies. The SDCBP2 Polyclonal Antibody is a reliable tool for investigating the function of SDCBP2, making it a valuable asset for researchers in the fields of cancer biology and drug discovery.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO41054 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO41054 at dilution of 1:100.
Background:
cytoplasm, extracellular exosome, plasma membrane, protein C-terminus binding, protein heterodimerization activity, protein homodimerization activity, intracellular signal transduction, intracellular transport, nervous system development
Synonyms:
Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2), SDCBP2, SITAC18
UniProt Protein Function:
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
NCBI Summary:
The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]
