SCYL2 Rabbit Polyclonal Antibody (CAB13178)
- SKU:
- CAB13178
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SCYL2 Rabbit Polyclonal Antibody |
SKU: | CAB13178 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SCYL2 (NP_060458.3). |
Sequence: | MESM LNKL KSTV TKVT ADVT SAVM GNPV TREF DVGR HIAS GGNG LAWK IFNG TKKS TKQE VAVF VFDK KLID KYQK FEKD QIID SLKR GVQQ LTRL RHPR LLTV QHPL EESR DCLA FCTE PVFA SLAN VLGN WENL PSPI SPDI KDYK LYDV ETKY GLLQ VSEG LSFL HSSV KMVH GNIT PENI ILNK SGAW KIMG FDFC VSST NPSE QEPK FPCK EWDP NLPS LCLP NPEY LAPE YILS VSCE TASD MYSL GTVM YAVF NKGK PIFE VNKQ DIYK SFSR QLDQ LSRL GSSS LTNI PEEV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | AMC4; AMCNACC; CVAK104; SCYL2 |
Positive Sample: | Mouse brain,Mouse heart,Mouse kidney,Rat brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Endosome membrane, Golgi apparatus, clathrin-coated vesicle, perinuclear region, trans-Golgi network membrane. |
Calculated MW: | 104kDa |
Observed MW: | 104kDa |
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 55681 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |