The SCYL2 Polyclonal Antibody (CAB13178) is a valuable tool for researchers studying the SCYL2 protein, which plays a key role in various cellular processes, including intracellular trafficking and signaling. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications.SCYL2, also known as DORF1 (DOCKing protein related 1), is involved in regulating the movement of proteins within cells and has been implicated in diseases such as cancer and neurodegenerative disorders. By enabling the detection and analysis of SCYL2 in different cell types, this antibody is ideal for immunology and cancer research studies aiming to understand the function and dysregulation of SCYL2 in various disease states.
Furthermore, insights gained from studying SCYL2 could lead to the development of novel therapeutic strategies targeting the protein in diseases where its dysregulation is implicated. By providing a means to study and analyze SCYL2 expression and activity, the SCYL2 Polyclonal Antibody is a valuable asset for researchers investigating the role of SCYL2 in health and disease.
Product Name:
SCYL2 Rabbit Polyclonal Antibody
SKU:
CAB13178
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SCYL2 (NP_060458.3).
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
55681
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCYL2 Rabbit pAb (CAB13178) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
