SCUBE3 Antibody (PACO12062)
- SKU:
- PACO12062
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SCUBE3 Antibody (PACO12062)
The SCUBE3 Antibody (PACO12062) is a potent tool for researchers studying SCUBE3, a secreted protein involved in various biological processes. This polyclonal antibody, generated using state-of-the-art techniques, exhibits high specificity and sensitivity for SCUBE3 detection in human samples. Validated for use in Western blot applications, the antibody allows for precise identification and quantification of SCUBE3 protein levels in different cell types.SCUBE3, also known as signal peptide-CUB-EGF domain-containing protein 3, plays a crucial role in cell signaling, development, and angiogenesis.
Its dysregulation has been linked to various diseases, including cancer and cardiovascular disorders. By targeting SCUBE3 with this antibody, researchers can gain insights into its functions and mechanisms, paving the way for potential therapeutic interventions in these pathological conditions.Overall, the SCUBE3 Antibody (PACO12062) is a valuable asset for studies in molecular biology, cell biology, and disease research, offering a dependable tool for exploring the roles of SCUBE3 in health and disease.
| Antibody Name: | SCUBE3 Antibody (PACO12062) |
| Antibody SKU: | PACO12062 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human SCUBE3 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | signal peptide, CUB domain, EGF-like 3;SCUBE3;CEGF3;DKFZp686B09105;DKFZp686B1223;DKFZp686D20108;FLJ34743 ; |
| UniProt Protein Function: | SCUBE3: Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cell surface Molecular Function:protein binding Biological Process: protein heterooligomerization; protein homooligomerization |
| NCBI Summary: | This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q8IX30 |
| NCBI GenInfo Identifier: | 74762488 |
| NCBI Gene ID: | 222663 |
| NCBI Accession: | Q8IX30.1 |
| UniProt Secondary Accession: | Q8IX30,Q5CZB3, Q86UZ9, Q8NAU9, A8K5A3, |
| UniProt Related Accession: | Q8IX30 |
| Molecular Weight: | 111,099 Da |
| NCBI Full Name: | Signal peptide, CUB and EGF-like domain-containing protein 3 |
| NCBI Synonym Full Names: | signal peptide, CUB domain and EGF like domain containing 3 |
| NCBI Official Symbol: | SCUBE3Â Â |
| NCBI Official Synonym Symbols: | CEGF3Â Â |
| NCBI Protein Information: | signal peptide, CUB and EGF-like domain-containing protein 3 |
| UniProt Protein Name: | Signal peptide, CUB and EGF-like domain-containing protein 3 |
| UniProt Gene Name: | SCUBE3Â Â |
| UniProt Entry Name: | SCUB3_HUMAN |
Related Products
