The SCUBE1 Polyclonal Antibody (PACO60208) is a valuable tool for researchers studying SCUBE1, a cell surface protein that plays a role in various biological processes. This antibody, produced in a rabbit host, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SCUBE1 protein, this antibody enables researchers to detect and analyze SCUBE1 in a variety of cell types, making it ideal for studies in cell biology and developmental biology.SCUBE1, also known as signal peptide-CUB-EGF domain-containing protein 1, is involved in multiple cellular functions, including cell adhesion, migration, and signaling pathways.
Its role in these processes makes it a promising target for research in a variety of fields, including stem cell research and organ development. Understanding the function of SCUBE1 could lead to valuable insights into how cells communicate and interact in complex biological systems, ultimately contributing to advancements in regenerative medicine and tissue engineering.
Antibody Name:
SCUBE1 Antibody (PACO60208)
Antibody SKU:
PACO60208
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 1 protein (453-566AA)
Immunofluorescence staining of Hela cells with PACO60208 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
Synonyms:
Signal peptide, CUB and EGF-like domain-containing protein 1, SCUBE1
UniProt Protein Function:
SCUBE1: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; external side of plasma membrane
Molecular Function:identical protein binding; protein heterodimerization activity; calcium ion binding
Biological Process: adult heart development; endothelial cell differentiation; blood coagulation; inflammatory response; protein homooligomerization; post-embryonic development
NCBI Summary:
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]
