The Scrib Polyclonal Antibody (CAB17450) is specifically designed for research involving Scrib, a protein known for its roles in cell polarity and tumor suppression. This antibody, produced in rabbits, has high reactivity with Scrib in human samples and is validated for use in Western blot applications. By binding to Scrib, this antibody allows for the detection and analysis of this protein in various cell types, making it ideal for studies in cell biology and cancer research.Scrib is a key player in cell polarity, which is essential for proper cell division and tissue organization. Dysregulation of Scrib has been implicated in various types of cancer, making it an important target for research aimed at understanding cancer development and progression.
By studying the function and regulation of Scrib, researchers can gain valuable insights into the mechanisms underlying cancer and potentially uncover new therapeutic targets for treatment.Overall, the Scrib Polyclonal Antibody (CAB17450) offers a valuable tool for investigating the roles of Scrib in cell polarity and cancer biology. Its high specificity and sensitivity make it a reliable choice for researchers looking to advance their understanding of these critical processes.
Product Name:
SCRIB Rabbit Polyclonal Antibody
SKU:
CAB17450
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human SCRIB (NP_874365.3).
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23513
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of MCF7, using SCRIB antibody (CAB17450) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
