The SCP2 Polyclonal Antibody (CAB5382) is a valuable tool for researchers studying SCP2, a protein involved in lipid metabolism and cholesterol transport. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SCP2 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in biochemistry and metabolic research.SCP2, also known as sterol carrier protein 2, plays a crucial role in the intracellular trafficking of cholesterol and other lipids.
Dysregulation of SCP2 has been linked to metabolic disorders and cardiovascular diseases, making it an important target for investigation. Understanding the function of SCP2 can provide insights into lipid metabolism pathways and potential therapeutic strategies for related conditions.Overall, the SCP2 Polyclonal Antibody is a reliable tool for researchers interested in studying SCP2 and its implications in lipid metabolism and cholesterol transport. Its specificity and sensitivity make it a valuable asset for furthering our understanding of these important biological processes.
Product Name:
SCP2 Rabbit Polyclonal Antibody
SKU:
CAB5382
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SCP2 (NP_001007099.1).
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6342
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse liver, using SCP2 Rabbit pAb (CAB5382) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
