The SCOC Monoclonal Antibody (PAC02976) is a valuable tool for researchers studying SCOC, a crucial component involved in protein degradation and cell cycle regulation. This antibody, produced in mice, shows high specificity for SCOC in human samples and is ideal for use in Western blot and immunofluorescence applications.SCOC, also known as short coiled-coil protein, is involved in the degradation of misfolded proteins and plays a role in maintaining cellular homeostasis.
Its association with cell cycle regulation makes it a promising target for studying diseases like cancer and neurodegenerative disorders. The SCOC antibody enables researchers to detect and analyze SCOC expression in various cell types, providing valuable insights into its function and potential therapeutic implications in disease contexts.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO29776 at dilution of 1:100.
Immunofluorescence staining of HepG2 cells with PACO29776 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO29776 at dilution of 1:100.
Background:
Positive regulator of amino acid, starvation-induced autophagy.
Synonyms:
Short coiled-coil protein, SCOC, SCOCO
UniProt Protein Function:
SCOC: Positive regulator of amino acid starvation-induced autophagy. Belongs to the SCOC family. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4q31.1Cellular Component: cytosol; endosome; Golgi membrane; trans-Golgi networkMolecular Function: protein bindingBiological Process: positive regulation of macroautophagy
UniProt Protein Details:
NCBI Summary:
This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
