The SCO2 Polyclonal Antibody (CAB7051) is a valuable tool for research involving the SCO2 protein, which is essential for the assembly of cytochrome c oxidase (COX) complex in the mitochondria. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SCO2 protein, researchers can detect and analyze its expression levels in a variety of cell types, making it an ideal choice for investigations in the fields of biochemistry and mitochondrial biology.
SCO2 is a crucial protein involved in the proper functioning of the mitochondrial respiratory chain, which plays a central role in cellular energy production. Mutations in the SCO2 gene can lead to severe mitochondrial disorders, highlighting the importance of studying this protein in the context of metabolic diseases and mitochondrial dysfunction. Research on SCO2 may provide insights into potential therapeutic targets for treating conditions associated with mitochondrial respiratory chain deficiencies.
Product Name:
SCO2 Rabbit Polyclonal Antibody
SKU:
CAB7051
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-266 of human SCO2 (NP_005129.2).
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6.
Purification Method:
Affinity purification
Gene ID:
9997
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCO2 Rabbit pAb (CAB7051) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
