The SCNN1B Polyclonal Antibody (CAB1765) is a powerful tool for researchers studying the SCNN1B gene, which encodes for the beta subunit of the epithelial sodium channel (ENaC). This antibody, produced in rabbits, specifically targets the SCNN1B protein and is highly reactive with human samples, making it an ideal choice for Western blot applications.ENaC plays a crucial role in regulating sodium reabsorption in the kidneys and maintaining electrolyte balance in the body. Dysregulation of ENaC function has been linked to various diseases, including hypertension, cystic fibrosis, and Liddle syndrome.
By targeting SCNN1B, researchers can gain insights into the regulation and function of ENaC in these disease contexts.The SCNN1B Polyclonal Antibody is a valuable tool for studying the molecular mechanisms underlying ENaC function and its role in disease pathogenesis. Its high specificity and reactivity make it an essential component for research in nephrology, pulmonary medicine, and other fields related to sodium balance and ion transport.
Product Name:
SCNN1B Rabbit Polyclonal Antibody
SKU:
CAB1765
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 406-640 of human SCNN1B (NP_000327.2).
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.
Purification Method:
Affinity purification
Gene ID:
6338
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCNN1B Rabbit pAb (CAB1765) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
