The SCNN1A Polyclonal Antibody (CAB5538) is a valuable tool for researchers studying the SCNN1A gene, which codes for a subunit of the epithelial sodium channel. This antibody, generated in rabbits, is highly specific to human SCNN1A protein and is suitable for use in Western blot applications. By targeting the SCNN1A protein, researchers can investigate its role in ion transport and its potential implications in various physiological processes.The SCNN1A gene is known to be involved in sodium reabsorption in the kidney and plays a critical role in maintaining fluid and electrolyte balance in the body.
Dysregulation of SCNN1A has been linked to disorders such as hypertension and cystic fibrosis, highlighting its importance in human health. The SCNN1A Polyclonal Antibody provides researchers with a reliable tool for studying the function and regulation of this gene, paving the way for advancements in the treatment of related disorders.
Product Name:
SCNN1A Rabbit Polyclonal Antibody
SKU:
CAB5538
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 105-225 of human SCNN1A (NP_001029.1).
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
6337
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using (CAB5538) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
