The SCN9A Antibody (PAC018874) offered by Assaygenie is a high-quality polyclonal antibody designed for research involving the SCN9A gene, which encodes for the sodium voltage-gated channel alpha subunit 9. This channel is crucial for the generation and conduction of action potentials in sensory neurons and plays a key role in pain perception.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for studying the expression and function of SCN9A in various physiological and pathological conditions. It has been validated for use in Western blot and immunohistochemistry applications, allowing for reliable detection and analysis of SCN9A protein levels in different cell types and tissues.
SCN9A has been implicated in various pain disorders, including inherited erythromelalgia and paroxysmal extreme pain disorder, highlighting its importance in pain sensation and perception. Research targeting SCN9A can provide valuable insights into the underlying mechanisms of pain conditions and potentially lead to the development of novel therapeutic interventions for pain management.By utilizing the SCN9A Antibody from Assaygenie, researchers can delve deeper into the role of SCN9A in pain signaling pathways and gain a better understanding of its involvement in pain disorders, ultimately contributing to the advancement of pain research and the development of targeted therapies for those suffering from chronic pain conditions.
Antibody Name:
SCN9A Antibody (PACO18874)
Antibody SKU:
PACO18874
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SCN9A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18874(SCN9A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18874(SCN9A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.
