The SCN5A Polyclonal Antibody (CAB16665) is a valuable tool for researchers studying the SCN5A protein, an important component of cardiac muscle function. This antibody, generated in rabbits, is highly specific and reactive to human samples, making it ideal for use in Western blot applications. By binding to the SCN5A protein, researchers can effectively detect and analyze its expression in various cell types, providing insights into cardiac function and potential implications for cardiovascular diseases.SCN5A, also known as the cardiac sodium channel, is crucial for the electrical signaling that regulates heart rhythm. Mutations in the SCN5A gene have been linked to various cardiac disorders, including long QT syndrome and Brugada syndrome.
Understanding the role of SCN5A in cardiac function is essential for developing targeted treatments for these conditions and advancing our knowledge of cardiac physiology.By utilizing the SCN5A Polyclonal Antibody (CAB16665), researchers can further explore the intricate mechanisms of cardiac muscle function and the potential implications of SCN5A dysregulation in cardiovascular diseases. This antibody provides a reliable tool for studying SCN5A expression and function, ultimately contributing to the development of novel therapeutic strategies for heart disorders.
Product Name:
SCN5A Rabbit Polyclonal Antibody
SKU:
CAB16665
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1950-2016 of human SCN5A (NP_932173.1).
endoplasmic reticulum, lateral plasma membrane, nucleolus, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, sarcolemma, T-tubule, Z disc
Calculated MW:
227kDa
Observed MW:
230-280kDa
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene have been associated with long QT syndrome type 3 (LQT3), atrial fibrillation, cardiomyopathy, and Brugada syndrome 1, all autosomal dominant cardiac diseases. Alternative splicing results in several transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse lung, using SCN5A antibody (CAB16665) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
