The SCN4B Polyclonal Antibody (CAB2154) is a valuable tool for researchers studying the SCN4B protein, a critical component of voltage-gated sodium channels. This antibody, produced in rabbits, is highly specific and reacts well with human samples. It is validated for use in Western blot applications, enabling the detection and analysis of SCN4B in various cell types.Voltage-gated sodium channels are essential for the initiation and propagation of action potentials in excitable cells, including neurons and muscle cells. SCN4B is a regulatory subunit that modulates the function of sodium channels, influencing excitability and electrical signaling in these cells.
Research on SCN4B is relevant to various fields, including neuroscience, cardiology, and muscle physiology.Understanding the role of SCN4B in health and disease can provide insights into conditions such as epilepsy, cardiac arrhythmias, and muscle disorders. By studying the function and regulation of SCN4B, researchers can uncover potential therapeutic targets for these conditions. The SCN4B Polyclonal Antibody is a valuable resource for investigating the intricacies of voltage-gated sodium channels and their impact on cellular physiology.
Product Name:
SCN4B Rabbit Polyclonal Antibody
SKU:
CAB2154
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-228 of mouse SCN4B (Q7M729).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
25kDa
Observed MW:
38kDa
Enables voltage-gated sodium channel activity. Acts upstream of or within sodium ion transmembrane transport. Located in intercalated disc. Is expressed in brain. Human ortholog(s) of this gene implicated in long QT syndrome 10. Orthologous to human SCN4B (sodium voltage-gated channel beta subunit 4).
Purification Method:
Affinity purification
Gene ID:
399548
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCN4B Rabbit pAb (CAB2154) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
