The SCN4B Antibody (PAC063815) is a high-quality research tool designed for scientists studying the SCN4B protein, a subunit of voltage-gated sodium channels which play a vital role in neuronal excitability and muscle contraction. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SCN4B in human samples, making it suitable for use in various experimental techniques such as Western blotting and immunohistochemistry.SCN4B is known to modulate the function of voltage-gated sodium channels, impacting action potential propagation and cellular excitability.
Dysregulation of SCN4B has been implicated in various neurological disorders and muscle diseases, making it a promising target for therapeutic intervention. By using the SCN4B Antibody, researchers can gain valuable insights into the role of SCN4B in health and disease, paving the way for the development of novel treatment strategies for conditions such as epilepsy, arrhythmias, and muscular dystrophy.
Antibody Name:
SCN4B Antibody (PACO63815)
Antibody SKU:
PACO63815
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Sodium channel subunit beta-4 protein (31-162AA)
Immunofluorescence staining of HepG2 cells with PACO63815 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain α sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Synonyms:
Sodium channel subunit beta-4, SCN4B
UniProt Protein Function:
SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q23.3Cellular Component: intrinsic to plasma membrane; voltage-gated sodium channel complexMolecular Function: sodium channel regulator activity; voltage-gated sodium channel activityBiological Process: cardiac muscle contraction; sodium ion transportDisease: Long Qt Syndrome 10
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
