The SCN4B Polyclonal Antibody (PACO01477) is a valuable tool for researchers studying the SCN4B protein, which plays a critical role in cardiac sodium channel function. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.SCN4B is a member of the sodium channel regulatory subunit beta family and is involved in modulating the voltage-dependent sodium channel complex in cardiac tissue. Dysregulation of SCN4B has been linked to cardiovascular diseases such as long QT syndrome and Brugada syndrome, making it a promising target for investigation in cardiac electrophysiology research.
By specifically binding to the SCN4B protein, this antibody enables the detection and analysis of SCN4B expression in various cell types, providing valuable insights into its function and potential implications in disease pathology. Researchers in the fields of cardiology, electrophysiology, and molecular biology will find this antibody indispensable for their studies on sodium channel regulation and cardiac function.
Antibody Name:
SCN4B Antibody
Antibody SKU:
PACO01477
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Scn4b.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SCN4B; Sodium channel subunit beta-4
UniProt Protein Function:
SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q23.3Cellular Component: intrinsic to plasma membrane; voltage-gated sodium channel complexMolecular Function: sodium channel regulator activity; voltage-gated sodium channel activityBiological Process: cardiac muscle contraction; sodium ion transportDisease: Long Qt Syndrome 10
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
