The SCN4A Antibody (PAC004988) is a valuable tool for researchers studying the SCN4A gene, which encodes for the alpha subunit of the voltage-gated sodium channel Nav1.4. This antibody, raised in rabbits, specifically targets the SCN4A protein and is highly reactive with human samples. Validated for use in Western blot applications, it allows for the detection and analysis of Nav1.4 expression in various cell types.Nav1.4 plays a crucial role in the excitability of skeletal muscle cells and is implicated in various muscle disorders, including myotonia and periodic paralysis.
Research into Nav1.4 function is essential for understanding the pathophysiology of these conditions and developing targeted treatments. The SCN4A Antibody facilitates the investigation of Nav1.4 expression levels and localization, making it an indispensable tool for studies in muscle biology and neuromuscular diseases.
Antibody Name:
SCN4A Antibody
Antibody SKU:
PACO04988
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Na+ CP type IValpha.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SCN4A; Sodium channel protein type 4 subunit alpha; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4
UniProt Protein Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
NCBI Summary:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
