The SCN3B Polyclonal Antibody (CAB10316) is a valuable tool for researchers studying the sodium channel protein, specifically SCN3B, which plays a crucial role in regulating neuronal excitability. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot and immunohistochemistry applications.SCN3B is a subunit of the voltage-gated sodium channel complex, essential for the generation and propagation of action potentials in neurons. Dysregulation of SCN3B has been implicated in various neurological disorders, including epilepsy, migraine, and neuropathic pain.
By targeting SCN3B with this antibody, researchers can investigate its expression levels and localization in different cell types and tissues, providing valuable insights into its functional roles.Understanding the role of SCN3B in neuronal function and dysfunction is critical for developing targeted therapies for neurological disorders. By utilizing the SCN3B Polyclonal Antibody, researchers can further elucidate the involvement of this protein in disease pathogenesis, paving the way for novel treatment strategies in neurology and pharmacology.
Product Name:
SCN3B Rabbit Polyclonal Antibody
SKU:
CAB10316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-160 of human SCN3B (NP_060870.1).
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
55800
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat brain, using SCN3B Rabbit pAb (CAB10316) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
