The SCN2B Polyclonal Antibody (CAB7723) is specifically designed for research involving SCN2B, a protein subunit of sodium channels that plays a crucial role in neuronal excitability and communication. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in a variety of applications including Western blot, immunofluorescence, and immunohistochemistry.SCN2B is known to be involved in regulating the function of sodium channels in the nervous system, impacting neuronal signaling and neurotransmission. Dysregulation of SCN2B has been implicated in various neurological disorders such as epilepsy, autism, and schizophrenia, making it an important target for research in neurobiology and neurology.
By using the SCN2B Polyclonal Antibody, researchers can detect and analyze the expression and localization of SCN2B in different cell types and tissues, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for studying the role of SCN2B in neuronal physiology and pathology, advancing our understanding of neurological disorders and potential treatment strategies.
Product Name:
SCN2B Rabbit Polyclonal Antibody
SKU:
CAB7723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-160 of human SCN2B (NP_004579.1).
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.
Purification Method:
Affinity purification
Gene ID:
6327
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SCN2B antibody (CAB7723) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
