The SCN2A Polyclonal Antibody (CAB10574) is a valuable tool for researchers studying SCN2A, a gene encoding a sodium channel protein that plays a critical role in neuronal excitability. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunohistochemistry.SCN2A is known to be involved in various neurological disorders, including epilepsy and autism spectrum disorders. Research on this gene and its protein product is essential for understanding the underlying mechanisms of these conditions and developing potential therapeutic interventions.
This polyclonal antibody recognizes the SCN2A protein, allowing for the detection and analysis of its expression in different cell types and tissues. Its high reactivity and specificity make it an ideal tool for investigating the role of SCN2A in normal neuronal function and disease pathology. Researchers in the fields of neuroscience and genetics will find this antibody indispensable for their studies.
Product Name:
SCN2A Rabbit Polyclonal Antibody
SKU:
CAB10574
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_001035232.1).
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCN2A Rabbit pAb (CAB10574) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
