The SCN1B Polyclonal Antibody (CAB10071) is a valuable tool for researchers studying SCN1B, a critical protein involved in ion channel regulation in the nervous system. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for Western blot applications.SCN1B is a multifunctional protein that plays a key role in the proper functioning of voltage-gated sodium channels in neurons. Dysregulation of SCN1B has been linked to various neurological disorders, including epilepsy and autism spectrum disorders.
By targeting SCN1B with this polyclonal antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.The ability to detect and analyze SCN1B in different cell types using this antibody makes it a valuable asset for studies in neuroscience, neurology, and pharmacology. By understanding the role of SCN1B in ion channel biology, researchers can pave the way for innovative approaches to treating neurological diseases and improving patient outcomes.
Product Name:
SCN1B Rabbit Polyclonal Antibody
SKU:
CAB10071
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human SCN1B (NP_950238.1).
Membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
25kDa
Observed MW:
30kDa
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6324
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SCN1B antibody (CAB10071) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
