The SCML2 Polyclonal Antibody (PAC061249) is a valuable tool for studying SCML2, a nuclear protein involved in epigenetic regulation and gene expression. This antibody, generated in rabbits, shows strong reactivity with human samples and has been validated for use in Western blot applications. By targeting the SCML2 protein, this antibody allows for the detection and analysis of SCML2 in various cell types, making it ideal for research in molecular biology and cancer biology.SCML2 plays a key role in chromatin organization and transcriptional regulation, making it a critical player in gene expression control.
Dysregulation of SCML2 has been implicated in various diseases, including cancer and developmental disorders. Therefore, studying the function and regulation of SCML2 is essential for unraveling its role in these pathologies and potentially identifying new therapeutic targets.Overall, the SCML2 Polyclonal Antibody is a valuable tool for researchers investigating the molecular mechanisms underlying gene expression and chromatin dynamics, with potential implications for understanding and treating various diseases.
Antibody Name:
SCML2 Antibody (PACO61249)
Antibody SKU:
PACO61249
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Sex comb on midleg-like protein 2 protein (466-620AA)
IHC image of PACO61249 diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Synonyms:
Sex comb on midleg-like protein 2, SCML2
UniProt Protein Function:
SCML2: a protein of unknown function. Contains a SAM (sterile alpha motif) and two MBT domains.Protein type: Transcription factorChromosomal Location of Human Ortholog: Xp22Cellular Component: nucleus; PcG protein complexMolecular Function: DNA binding; transcription factor activityBiological Process: anatomical structure morphogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]