The SCGB1D2 Monoclonal Antibody (PAC019941) is a valuable tool for researchers studying SCGB1D2, a member of the secretoglobin superfamily implicated in lung development and diseases. This antibody, developed using hybridoma technology, specifically targets human SCGB1D2 and is suitable for use in various research applications, including immunofluorescence and flow cytometry.SCGB1D2, also known as Clara Cell Protein 40 (CCP40), is thought to play a role in respiratory epithelial cell differentiation and lung inflammation. Research has shown its potential involvement in lung cancer, chronic obstructive pulmonary disease (COPD), and other pulmonary disorders.
By studying the expression and function of SCGB1D2, scientists can gain insights into lung biology and potentially discover new therapeutic targets for respiratory diseases.With its high specificity and sensitivity, the SCGB1D2 Monoclonal Antibody is a reliable tool for investigating the biological functions of SCGB1D2 in lung physiology and pathology. Its use in research may lead to advancements in the diagnosis and treatment of respiratory conditions, ultimately improving patient care and outcomes.
Antibody Name:
SCGB1D2 Antibody (PACO19941)
Antibody SKU:
PACO19941
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SCGB1D2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19941(SCGB1D2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19941(SCGB1D2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.
Synonyms:
secretoglobin, family 1D, member 2
UniProt Protein Function:
SCGB1D2: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones. Belongs to the secretoglobin family. Lipophilin subfamily.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 11q13Cellular Component: extracellular space
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
