The SCD Polyclonal Antibody (CAB16429) is a valuable tool for researchers studying stearoyl-CoA desaturase (SCD), an enzyme involved in the biosynthesis of monounsaturated fatty acids. This antibody, derived from rabbits, demonstrates high reactivity with human samples and is suitable for Western blot applications. By binding to SCD, this antibody allows for the detection and analysis of the enzyme in various cell types, making it ideal for investigations in the fields of metabolism and lipid metabolism research.SCD plays a vital role in lipid metabolism by catalyzing the desaturation of saturated fatty acids to monounsaturated fatty acids, which are not only essential for membrane structure but also play key roles in lipid signaling pathways.
Dysregulation of SCD has been implicated in various metabolic disorders, including obesity, diabetes, and cardiovascular disease. Research on SCD using this polyclonal antibody can provide important insights into the physiological and pathological roles of this enzyme, offering potential therapeutic targets for related metabolic disorders.
Product Name:
[KO Validated] SCD Rabbit Polyclonal Antibody
SKU:
CAB16429
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCD (NP_005054.3).
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
Purification Method:
Affinity purification
Gene ID:
6319
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SCD Rabbit pAb (CAB16429) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
