The Scarf2 Polyclonal Antibody (PAC022585) is a valuable tool for researchers studying Scarf2, a protein involved in various cellular processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity to human samples, making it ideal for Western blot applications. By targeting the Scarf2 protein, this antibody enables researchers to analyze its expression and function in different cell types, making it a versatile tool for studies in molecular biology and cell signaling pathways.Scarf2, also known as a potential scaffold protein, plays a crucial role in cellular signaling and protein interactions, making it a key player in processes such as cell growth, differentiation, and apoptosis.
The importance of Scarf2 in fundamental cellular functions suggests its potential as a therapeutic target for diseases ranging from cancer to neurological disorders. Investigating the role of Scarf2 using this antibody is essential for gaining insights into its function and exploring its potential as a target for drug development.
Antibody Name:
SCARF2 Antibody (PACO22585)
Antibody SKU:
PACO22585
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SCARF2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using SCARF2 antibody.
Background:
Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) By similarity.
Synonyms:
Scavenger receptor class F member 2 Scavenger receptor expressed by endothelial cells 2 protein; SREC-II; SRECRP-1 SCARF2;
UniProt Protein Function:
SREC-II: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Defects in SCARF2 are the cause of Van den Ende-Gupta syndrome (VDEGS). A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 22q11.21Cellular Component: focal adhesion; integral to membraneMolecular Function: protein binding; scavenger receptor activityBiological Process: heterophilic cell adhesion; receptor-mediated endocytosisDisease: Van Den Ende-gupta Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
