The Scarf2 Polyclonal Antibody (PACO05692) is a valuable tool for researchers studying the Scarf2 protein, which has been shown to play a role in cell signaling pathways and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting and immunofluorescence.Scar2, also known as Signal Transducing Adaptor Family Member 2, is involved in mediating cellular responses to external stimuli and has been implicated in various biological processes, including cell growth, differentiation, and survival.
Research on Scarf2 is particularly relevant in the fields of cell biology and cancer research, where dysregulation of signaling pathways can lead to abnormal cell behavior and disease progression.By using the Scarf2 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of Scarf2 in different cell types and disease contexts. This antibody is a valuable tool for studies investigating the role of Scarf2 in cellular processes and may ultimately contribute to the development of targeted therapies for diseases associated with dysregulated signaling pathways.
Antibody Name:
SCARF2 Antibody (PACO05692)
Antibody SKU:
PACO05692
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human SREC-II.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SCARF2; SREC2; SREPCR; Scavenger receptor class F member 2; SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II
UniProt Protein Function:
SREC-II: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Defects in SCARF2 are the cause of Van den Ende-Gupta syndrome (VDEGS). A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 22q11.21Cellular Component: focal adhesion; integral to membraneMolecular Function: protein binding; scavenger receptor activityBiological Process: heterophilic cell adhesion; receptor-mediated endocytosisDisease: Van Den Ende-gupta Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
