The Scarf1 Polyclonal Antibody (PACO12042) is a valuable tool for research involving the Scarf1 protein, a key regulator of cell migration and invasion. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. It specifically targets the Scarf1 protein, allowing for accurate detection and analysis in various cell types.Scarf1, also known as Scarf 1 or PPARAIP, is involved in various cellular processes such as focal adhesion dynamics and actin cytoskeleton organization, making it a crucial player in cancer metastasis and invasion.
Its role in cell motility and invasion highlights its potential as a therapeutic target for cancer treatment and research efforts aimed at understanding metastatic processes.Utilizing the Scarf1 Polyclonal Antibody can provide valuable insights into the molecular mechanisms underlying Scarf1 function and its impact on cancer progression. By studying the expression and localization of Scarf1 in different cellular contexts, researchers can further unravel its role in cancer biology and potentially develop targeted therapies to inhibit its function in metastatic disease.
scavenger receptor class F, member 1;SCARF1;KIAA0149;MGC47738;SREC ;
UniProt Protein Function:
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth ().
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
