The SCARB2 Polyclonal Antibody (CAB12723) is a valuable tool for researchers studying SCARB2, a protein involved in cellular processes such as lipid metabolism and intracellular trafficking. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the SCARB2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component in studies related to metabolism, cellular signaling, and disease mechanisms.SCARB2, also known as scavenger receptor class B member 2, plays a crucial role in maintaining cellular homeostasis by mediating the uptake and transport of various molecules, including lipids and proteins.
Its involvement in these processes makes it a compelling target for research into metabolic disorders, neurodegenerative diseases, and viral infections. By unraveling the functions of SCARB2, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic strategies.Overall, the SCARB2 Polyclonal Antibody (CAB12723) offers a reliable and efficient means of studying SCARB2 and its role in cellular physiology and pathology. Its high specificity and versatility make it an indispensable tool for scientists seeking to expand their understanding of lipid metabolism, intracellular transport, and related disease processes.
Product Name:
SR-B2/LIMPII Rabbit Polyclonal Antibody
SKU:
CAB12723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human SR-B2/LIMPII (NP_005497.1).
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
950
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SR-B2/LIMPII Rabbit pAb (CAB12723) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
