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SR-B2/LIMPII Rabbit Polyclonal Antibody (CAB12723)

SKU:
CAB12723
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:SR-B2/LIMPII Rabbit Polyclonal Antibody
SKU:CAB12723
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human SR-B2/LIMPII (NP_005497.1).
Sequence:GLFY EKNG TNDG DYVF LTGE DSYL NFTK IVEW NGKT SLDW WITD KCNM INGT DGDS FHPL ITKD EVLY VFPS DFCR SVYI TFSD YESV QGLP AFRY KVPA EILA NTSD NAGF CIPE GNCL GSGV LNVS ICKN GAPI IMSF PHFY QADE RFVS AIEG MHPN QEDH ETFV DINP LTGI ILKA A
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:1000 - 1:3000 IF/ICC,1:50 - 1:200
Synonyms:AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII; SR-B2/LIMPII
Positive Sample:HeLa,HepG2,Mouse heart,Mouse Lung,Mouse Liver,Rat Lung
Conjugate:Unconjugated
Cellular Localization:Lysosome membrane, Multi-pass membrane protein.
Calculated MW:54kDa
Observed MW:80kDa

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:950
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using SR-B2/LIMPII Rabbit pAb (CAB12723) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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