| UniProt Protein Function: | SCAMP5: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. Belongs to the SCAMP family. SCAMP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cell junction; Golgi membrane; integral to membrane; plasma membrane; recycling endosome membrane; SNARE complex; synaptic vesicle membrane; trans-Golgi network membraneMolecular Function: protein bindingBiological Process: exocytosis; negative regulation of endocytosis; positive regulation of calcium ion-dependent exocytosis; positive regulation of cytokine secretion; protein transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TAC9 |
| NCBI GenInfo Identifier: | 296010971 |
| NCBI Gene ID: | 192683 |
| NCBI Accession: | NP_001171582.1 |
| UniProt Secondary Accession: | Q8TAC9,Q8N3M4, B3KPJ7, B7Z762, D3DW71 |
| UniProt Related Accession: | Q8TAC9 |
| Molecular Weight: | 17,932 Da |
| NCBI Full Name: | secretory carrier-associated membrane protein 5 |
| NCBI Synonym Full Names: | secretory carrier membrane protein 5 |
| NCBI Official Symbol: | SCAMP5Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | secretory carrier-associated membrane protein 5 |
| UniProt Protein Name: | Secretory carrier-associated membrane protein 5 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Secretory carrier-associated membrane protein |
| UniProt Gene Name: | SCAMP5Â Â |
| UniProt Entry Name: | SCAM5_HUMAN |
