The SCAMP5 Polyclonal Antibody (PACO39966) is specially designed for research involving SCAMP5, a cell surface protein involved in intracellular membrane trafficking and synaptic vesicle recycling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SCAMP5 protein, this antibody allows for the detection and analysis of SCAMP5 expression in various cell types, making it an ideal tool for studies in neuroscience and cell biology.SCAMP5, also known as secretory carrier membrane protein 5, plays a crucial role in regulating the trafficking of secretory vesicles in neurons and other cell types.
Its involvement in synaptic vesicle recycling suggests a potential role in neurotransmission and synaptic plasticity, making it a key target for research in neurobiology and neurodegenerative diseases. Understanding the function of SCAMP5 could provide valuable insights into neurological disorders and may lead to the development of novel therapeutic strategies aimed at modulating synaptic function.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39966 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO39966 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.
Synonyms:
Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5), SCAMP5
UniProt Protein Function:
SCAMP5: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. Belongs to the SCAMP family. SCAMP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cell junction; Golgi membrane; integral to membrane; plasma membrane; recycling endosome membrane; SNARE complex; synaptic vesicle membrane; trans-Golgi network membraneMolecular Function: protein bindingBiological Process: exocytosis; negative regulation of endocytosis; positive regulation of calcium ion-dependent exocytosis; positive regulation of cytokine secretion; protein transport
